pilocarpine相关论文
mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model
In pilocarpine induced status epilepticus (PISE) in metabotropic glutamate receptor 5 (mGluR5) knock-out (mGluR5-/-) and......
The antiepileptic effect of the glycolytic inhibitor 2-deoxy-D-glucose is mediated by upregulation o
Metabolic modulation of neuronal excitability is becoming increasingly important as an antiepileptic therapy.It was repo......
Epilepsy is the third most common chronic brain disorder, however, little is known about the underlying mechanisms.The p......
Increased expression of galanin and its receptors in the rat hippocampus during epileptogenesis in t
The neuropeptide Galanin (GAL) is widely distributed throughout the brain.So far, three galanin receptors have been clon......
Proliferation changes in hippocampal neurons following pilocarpine-induced intractable epilepsy in a
Epilepsy can lead to the changes in neurons residing in the dentate gyrus. The present study aimed to observe the cell d......
Molecular Mechanism of Bovine Trabecular Meshwork Cells Apoptosis Induced by Dexamethasone and Prote
Purpose: To study the molecular mechanism of trabecular meshwork cells apoptosis induced by dexamethasone and the protec......
Correlation Study on Expression of GST-π Protein in Brain Tissue and Peripheral Blood of Epilepsy Ra
Previous studies have suggested that glutathione-S-transferase π (GST-π) over-expression in the brain tissue is associ......
Dapiprazole是一种肾上腺素α_1-受体阻滞剂,作者采用随机双盲法研究0.5%Timolol联合0.5%Dapiprazole或联合2%Pilocarpine治疗青......
目的探讨Ｐｉｌｏｃａｒｐｉｎｅ是否具有促使内耳分泌细胞功能亢进作用。方法 皮下注射Ｐｉｌｏ－ｃａｒｐｉｎｅ，用圆窗电极记录栗鼠ＣＭ，ＣＡＰ，ＳＰ，观察在用药前以及用药后３０’、６０’、９０’、１２０’、１５０’、１８０......
目的探讨小鼠匹鲁卡品癫痫持续状态模型(status epilepticus,SE)建立的优化给药策略。方法 98只ICR小鼠随机分为7组,每组14只,分别......
Muscarinic Receptor Agonists Protect Cultured Bovine Trabecular Meshwork Cells against Apoptosis Ind
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用.但是,由于通过实验方法鉴别Cx43间隙连接通道(......
Impact of Combination Use of 0.004%Travoprost and 2%Pilocarpine on Matrix Metalloproteinases Synthes
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Proliferation changes in hippocampal neurons following pilocarpine-induced intractable epilepsy in a
Epilepsy can lead to the changes in neurons residing in the dentate gyrus. The present study aimed to observe the cell d......
目的 探讨Ghrelin治疗匹罗卡品诱导的癫(癎)大鼠大脑皮层核因子(NF)-κB和肿瘤坏死因子(TNF)-α基因和蛋白表达水平的变化.方法 建......
Muscarinic Receptor Agonists Protect Cultured Bovine Trabecular Meshwork Cells against Apoptosis Ind
Purpose:To study whether muscarinic receptor agonists can protect cultured bovine trabecular meshwork cells against apop......
Molecular Mechanism of Bovine Trabecular Meshwork Cells Apoptosis Induced by Dexamethasone and Prote
Purpose: To study the molecular mechanism of trabecular meshwork cells apoptosis induced by dexamethasone and the protec......
目的 探讨褪黑素(Mel)抗癫痫作用的机制.方法 采用匹罗卡品(PILO)诱导大鼠癫痫持续状态(SE)模型,用免疫组化技术检测大鼠SE后4个时......
Impact of Combination Use of 0.004%Travoprost and 2%Pilocarpine on Matrix Metalloproteinases Synthes
Objective To explore the impact of combination use of prostaglandin analogue and cholinergic agonists on main matrix met......
Correlation Study on Expression of GST-π Protein in Brain Tissue and Peripheral Blood of Epilepsy Ra
Previous studies have suggested that glutathione-S-transferase π (GST-π) over-expression in the brain tissue is associ......
Background Curcumin,an active ingredient of turmeric with antioxidant and anti-inflammatory properties has recently been......
目的:针对药理学课程存在内容复杂,理论抽象,传统教学模式教学形式单一、枯燥乏味等问题,将微课引入药理学教学过程,激发学生学习......
目的 探讨褪黑素(melatonin,Mel)对匹罗卡品(pilocarpine,PILO)致痫大鼠行为及脑电图改变的影响.方法 通过腹腔注射(intraperitone......
目的 观察tariquidar（TQD）能否避开颞叶内侧癫痫（MTLE）模型鼠P糖蛋白（Pgp）过表达的外排作用将抗癫痫药物输送至脑。方法 锂-匹罗卡品诱导......
为探讨匹罗卡品家兔点眼对葡萄膜巩膜途径房水流出色的影响，用1％匹罗卡品（Pilocarpine，PC）对家免单侧点眼。并用0.1mmol／L异硫氰酸荧光素......
目的探讨褪黑素在匹罗卡品致痫大鼠模型中的抗癫痫作用及其机制.方法采用匹罗卡品癫痫模型,观察长期给予褪黑素对匹罗卡品致痫大鼠......
目的：比较研究毛果芸香碱刺激和非刺激条件下家兔唾液、血液和尿液中氯胺酮及代谢物去甲氯胺酮的含量。方法：实验家兔分为毛果芸香碱......
为探讨毛果芸香碱对角膜内皮的影响，对白内障囊外摘除加后房型人工晶体（ＩＯＬ）植入术中前房应用０．１％毛果芸香碱缩瞳的２３只眼，术后３－６上月使用接触型内......
给兔icv毛果芸香碱,出现抽搐、流涎、咀嚼,脑电呈低幅快波,呼吸兴奋,icv槟榔碱,兔轻度抽搐、流涎,脑电呈双相反应,呼吸兴奋作用短......
本文以兔呼吸频率、通气量和血气作为指标,观察到iv吗啡0.5～4.0mg/kg产生剂量依赖性呼吸抑制。icv匹鲁卡品2.5mg/kg能完全逆转这一......
给兔侧脑室注射阿托品有兴奋呼吸作用,且可增强毛果芸香碱、氨甲酰甲胆碱、槟榔碱兴奋呼吸效应;东莨菪碱对呼吸影响不明显,但却可......
目的研究边缘系统癫痫发作后海马颗粒细胞生长相关蛋白(GAP-43 )基因表达变化.方法建立匹罗卡品急、慢性癫痫模型,用原位杂交方法......
放射受体结合试验表明大鼠大脑皮层存在M_1受体(约90％)、M_2受体(约10％);东莨菪碱对M_1受体亲和力高于M_2受体,阿托品对M_2受体亲和......
大静脉注射哌仑西平０．０５～５ｍｇ／ｋｇ，呼吸频率减慢，潮气量、每分通气量减少，ＰａＯ２明显下降，ＰａＣＯ２显著上升，均呈剂量依赖关系。与匹鲁卡品合用两者相互拮抗。结果提......
目的 探讨兴奋或抑制汗液分泌过程中水通道蛋白-5（AQP5）在汗腺组织的分布及表达变化。方法应用硅橡胶印模及免疫荧光技术测定小鼠在......
目的：建立高效液相色谱测定兔眼房水中匹罗卡品含量的方法。探讨匹罗卡品溶液、乳浊液在兔眼房水中经时过程的异同。方法：色谱条件：硅......
目的探讨用激光周边虹膜切除术治疗长期匹罗卡品点眼的临床前期原发性闭角型青光眼(PACG).方法临床前期PACG42例42眼,匹罗卡品点眼......
本文给兔侧脑室、犬椎动脉以及静脉注射东莨菪碱，从呼吸频率、潮气量、通气量及血气分析多项指标皆观察到东莨菪碱有明显抑制作用，且......
目的：探讨抗青光眼药物毛果芸香碱和布林佐胺滴眼液及各自的防腐剂三氯叔丁醇和氯化苯甲烃胺（BAC）对兔眼表组织的影响。方法：选取新西......
目的：观察2-甲基6-苯基乙炔基嘧啶（MPEP）在毛果芸香碱诱导的癫痫小鼠动物模型中的抗抽搐及对小鼠大脑神经元的保护作用。方法：取5—6周......
目的观察丙戊酸钠对氯化锂-匹罗卡品癫痫鼠模型海马区B1及B2激肽受体(KB2R)表达的影响并探讨其作用机制。方法健康Wistar大鼠35只,......
目的:探讨细胞外信号调节激酶在癫痫持续状态(SE)大鼠脑内的活性变化规律及其意义.方法:建立氯化锂-匹罗卡品癫痫持续状态模型,在......
目的应用Fluoro-Jade C（FJC）在小鼠匹罗卡品癫痫模型中探测新大脑皮质结构中神经元的变性情况。方法雄性昆明种小鼠10只（对照组5只,匹......
目的应用Fluoro-Jade C（FJC）染色方法在小鼠匹罗卡品癫痫模型中探测岛皮质结构中神经元的变性情况,以了解岛皮质结构在慢性颞叶癫痫......
目的：比较不同剂量毛果芸香碱眼液用于治疗前房积血后的疗效及并发症。方法；对我院收治的工级和Ⅱ级前房积血患者161例随机分成四组：......
目的探讨匹罗卡品诱导慢性癫痫大鼠海马齿状颗粒细胞苔藓纤维突触重建与神经营养素受体TrkB表达的关系.方法取匹罗卡品诱导大鼠急......
目的探讨颞叶癫痫的发病机制。方法取健康雄性SD大鼠制成颞叶癫痫模型，用免疫组织化学和原位杂交技术对匹罗卡品致痫后不同时间点CA......
目的应用FluoroJadeC（FJC）染色方法观察小鼠匹罗卡品癫模型丘脑神经元变性情况,以了解丘脑结构在慢性颞叶癫发生中的病理变化和癫反......
目的研究锂-匹罗卡品颞叶癫模型大鼠致后性发作的行为学特点及海马结构病理改变的动态变化。方法将所有Wistar大鼠随机分为......
Molecular Mechanism of Bovine Trabecular Meshwork Cells Apoptosis Induced by Dexamethasone and Prote
Purpose: To study the molecular mechanism of trabecular meshwork cells apoptosis induced by dexamethasone and the protec......
